Ebselen | Glutathione peroxidase mimic

Ebselen (60940-34-3) is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent.¹ Displays protective effects in reperfusion injury and stroke.² Ebselen is an excellent scavenger of peroxynitrite.³ Acts as a glutathione peroxidase mimetic.⁴ Cell permeable.

References/Citations
1) Schewe et al. (1995), Molecular actions of ebselen - an anti-inflammatory antioxidant; Gen. Pharmacol., 26 1153
2) Parnham et al. (2000), Ebselen: prospective therapy for cerebral ischaemia; Expert. Opin. Investig. Drugs, 9 607
3) Masumoto et al. (1996), Kinetic study of the reaction of ebselen with peroxynitite; FEBS Lett., 398 179
4) Nakamura et al. (2002), Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis; J. Biol. Chem., 277 2687