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Product Details

Echinomycin | HIF-1alpha inhibitor

Echinomycin is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice against relapsed acute myeloid leukemia with no effect on hematopoietic stem cells.2 Selectively eliminates cancer stem cells in mouse lymphoma and human AML xenogeneic models.3 A very useful tool for probing genes regulated by HIF1α4

References/Citations

1) Kong et al. (2005), Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity; Cancer Res., 65 9047
2) Wang et al. (2014), Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells; Blood, 124 1127
3) Wang et al. (2011), Targeting HIF1α eliminates cancer stem cells in hematological malignancies; Cell Stem Cell., 8 399
4) Li et al. (2015), Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia; Cell Stress Chaperones, 20 507

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Catalog#  10-2424-0001

$90.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
512-64-1
Catalog Number:
10-2424
Activity:
HIF1α inhibitor
Alternate Names:
Quinomycin A; NSC-13502
Molecular Weight:
1101.26
Molecular Formula:
C51H64N12O12S2
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
White to beige solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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