Embelin | XIAP inhibitor/Apoptosis inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $55.00 | ||
| 50 mg | $220.00 |
Embelin (550-24-3) inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged.1 Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells.3 Possesses anti-inflammatory and analgesic activity in vivo.4 Cell-permeable.
References/Citations:
1) Modak et al. (2013), Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor; ACS Chem. Biol., 8 1311
2) Nikolovska-Coleska et al. (2004), Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database; J. Med. Chem., 47 2430
3) Shah et al. (2016), Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells; Pharmacol. Rep., 68 638
4) Chitra et al. (1994), Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.; Chemotherapy, 40 109
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Embelin (550-24-3) inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged.1 Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells.3 Possesses anti-inflammatory and analgesic activity in vivo.4 Cell-permeable.
References/Citations:
1) Modak et al. (2013), Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor; ACS Chem. Biol., 8 1311
2) Nikolovska-Coleska et al. (2004), Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database; J. Med. Chem., 47 2430
3) Shah et al. (2016), Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells; Pharmacol. Rep., 68 638
4) Chitra et al. (1994), Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.; Chemotherapy, 40 109
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