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Product Details

Embelin | XIAP inhibitor, Apoptosis inhibitor

Embelin (550-24-3) inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1.  Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.

References/Citations

1) Modak et al. (2013), Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor; ACS Chem. Biol., 8 1311
2) Nikolovska-Coleska et al. (2004), Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database; J. Med. Chem., 47 2430
3) Shah et al. (2016), Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells; Pharmacol. Rep., 68 638
4) Chitra et al. (1994), Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.; Chemotherapy, 40 109

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Focus Biomolecules cell signaling supplier, chemical structure Embelin | XIAP inhibitor, Apoptosis inhibitor | CAS 550-24-3

Catalog#  10-2959-0010

$50.00
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CAS:
550-24-3
Catalog Number:
10-2959
Activity:
XIAP inhibitor, Apoptosis inhibitor
Chemical Name:
2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
Molecular Weight:
286.65
Molecular Formula:
C17H26O4
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming)
Physical Properties:
Dark orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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