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Product Details

Emetine hydrochloride | Protein synthesis inhibitor

Emetine hydrochloride (483-18-1) is one of the active ingredients of ipecac root extract, used as an emetic.1 Induces apoptosis in breast cancer cells via inhibition of Wnt/β-catenin signaling.2 Inhibits Zika and Ebola virus in vitro and in vivo, targeting viral entry and replication by inhibiting viral RNA polymerase and host lysosomal function.3 Also inhibits SARS-CoV-2 replication in cells (EC50 for viral load reduction is 0.46 μM).4 A useful agent for inhibiting protein synthesis in eukaryotic cells by virtue of its inhibition of the ribosome 40S subunit.5.

References/Citations
1) Lee et al. (2008), Ipecacuanha: the South American vomiting root; J R Coll. Physicians Edinb., 38 355
2) Sun et al. (2019), Emetine Exhibits Anticancer Activity in Breast Cancer Cells as an Antagonist of Wnt/β-catenin Signaling; Oncol. Rep., 42 1735
3) Yang et al. (2018), Changing cancer survival in China during 2003-2015: a pooled analysis of 17 population-based cancer registries; Cell Discov., 4 31
4) Choy et al. (2020), Remdesivir, Lopinavir, and Homoharringtonine Inhibit SARS-CoV-2 Replication in Vitro; Antivir. Res., 178 104786
5) Cuyas et al. (2015), Anti-protozoal and Anti-Bacterial Antibiotics That Inhibit Protein Synthesis Kill Cancer Subtypes Enriched for Stem Cell-Like Properties; Cell Cycle, 14 3527

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Catalog#  10-3001-0050

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
483-18-1
Catalog Number:
10-3001
Activity:
Protein synthesis inhibitor
Chemical Name:
(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine, dihydrochloride, hydrate
Molecular Weight:
553.56
Molecular Formula:
C29H40N2O4 • 2HCL (XH2O)
Solubility:
Soluble in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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