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Flavopiridol HCl | CDK inhibitor

Flavopiridol HCl (131740-09-5) is a cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase.1 Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells.2 Potentiates the effects of topoisomerase I inhibitors by suppressing Rad51 expression in a p53-dependent manner. Flavopiridol HCl displays potent antiviral activity against HIV-1 and HSV-1 in vitro.4


1) Kaur et al. (1992), Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275;  J. Natl. Cancer Inst., 84 1736
2) Cartee et al. (2002), Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways;  Mol. Pharmacol., 61 1313
3) Ambrosini et al. (2008), The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner;  Cancer Res. 68 2312
4) Schang et al. (2004), Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication;  Biochim. Biophys. Acta, 1697 197

Focus Biomolecules cell signaling reagent supplier, chemical structure of Flavopiridol HCl | CDK inhibitor | CAS 131740-09-5

Catalog#  10-3063

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Catalog Number:
CDK inhibitor
Chemical Name:
3-(3-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, hydrochloride
Alternate Names:
L 86-8275; Alvocidib; NSC-649890
Molecular Weight:
Molecular Formula:
C21H20ClNO5 &bul; HCl
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 40 mg/ml).
Physical Properties:
Light yellow solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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