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Product Details

Trifluorothymidine | Thymidylate synthase inhibitor / Anti-cancer agent

Trifluorothymidine (70-00-8) is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2  After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes.3 Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.4


1) Bijnsdorp et al. (2010), Differential activation of cell death and autophagy results in an increaded cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells; Int. J. Cancer, 126 2457
2) Temmink et al. (2010), Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2; Mol. Cancer Ther., 9 1047
3) Suzuki et al. (2011), Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes; Int. J. Oncol., 39 263
4) Yu et al. (2015), Small molecules enhance CRISPR genome editing in pluripotent stem cells; Cell Stem Cell, 16 142

Focus Biomolecules reagent supplier, chemical structure of Trifluorothymidine | Thymidylate synthase inhibitor | CAS 70-00-8

Catalog#  10-1283-0050

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Catalog Number:
Thymidylate synthase inhibitor / Anti-cancer agent
Chemical Name:
Alternate Names:
α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside; Trifluridine; TFT
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)
Physical Properties:
Off-white solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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