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Product Details

Trifluorothymidine | Thymidylate synthase inhibitor / Anti-cancer agent

Trifluorothymidine (70-00-8) is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2  After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes.3 Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.4

References/Citations

1) Bijnsdorp et al. (2010), Differential activation of cell death and autophagy results in an increaded cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells; Int. J. Cancer, 126 2457
2) Temmink et al. (2010), Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2; Mol. Cancer Ther., 9 1047
3) Suzuki et al. (2011), Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes; Int. J. Oncol., 39 263
4) Yu et al. (2015), Small molecules enhance CRISPR genome editing in pluripotent stem cells; Cell Stem Cell, 16 142

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Catalog#  10-1283-0050

$45.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
70-00-8
Catalog Number:
10-1283
Activity:
Thymidylate synthase inhibitor / Anti-cancer agent
Chemical Name:
2’-Deoxy-5-trifluoromethyluridine
Alternate Names:
α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside; Trifluridine; TFT
Molecular Weight:
296.20
Molecular Formula:
C10H11F3N2O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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