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Product Details

Endosidin 2 | Exocytosis and endosomal recycling inhibitor

Endosidin-2 (1839524-44-5) binds to the EXO70 subunit of the exocyst complex which results in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. EXO70 is a component of the octameric exocyst complex which tethers post-Golgi vesicles to the plasma membrane before SNARE- mediated membrane fusion.2 Endosidin-2 was previously identified as a plant endomembrane trafficking disruptor.3 Inhibits intracellular glucose transporter, GLUT4 trafficking to the membrane and impairs glucose uptake in response to insulin.It is a valuable new tool for the study of exocytosis.


1) Zhang et al. (2016), Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis;  Proc. Natl. Acad. Sci. USA, 113 E41
2) Novick et al. (1980), Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway;  Cell, 21 205
3) Drakakaki et al. (2011), Clusters of bioactive compounds target dynamic endomembrane networks in vivo;  Proc. Natl. Acad. Sci. USA, 108 17850

4) Fujimoto et al. (2019), The Exocyst Complex Regulates Insulin-Stimulated Glucose Uptake of Skeletal Muscle Cells; Am. J. Physiol. Endocrinol. Metab. 317(6) E957

Focus Biomolecules supplier, chemical structure Endosidin 2 | Exocytosis & endosomal recycling inhibitor | CAS 1839524-44-5

Catalog#  10-1583

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Catalog Number:
Exocytosis and endosomal recycling inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (greater than 40 mg/ml), in DMF (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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