Eniluracil | Dihydropyrimidine dehydrogenase inhibitor

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.^1,2,3  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).  Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

References/Citations

1) Porter et al. (1992), Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem., 267 5236
2) Baccalnari et al. (1993), 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA, 90 11064
3) Schilsky and Kindler (2000) Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs, 9 1635