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Eniluracil | Dihydropyrimidine dehydrogenase inhibitor

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1,2,3  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).  Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

References/Citations

1) Porter et al. (1992), Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem., 267 5236
2) Baccalnari et al. (1993), 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA, 90 11064
3) Schilsky and Kindler (2000) Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs, 9 1635

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Focus Biomolecules supplier, chemical structure of Eniluracil | Dihydropyrimidine dehydrogenase inhibitor | CAS 59989-18-3

Catalog#  10-4600

$40.00
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CAS:
59989-18-3
Catalog Number:
10-4600
Activity:
Dihydropyrimidine dehydrogenase inhibitor
Chemical Name:
5-Ethynyluracil
Alternate Names:
GW776C85
Molecular Weight:
136.11
Molecular Formula:
C6H4N2O2
Solubility:
Soluble in DMSO
Physical Properties:
Yellow solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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