EPAC 5376753 | EPAC inhibitor

Catalog Number:
10-1564
Activity:
EPAC inhibitor
Chemical Name:
5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Molecular Weight:
367.21
Molecular Formula:
C15H8Cl2N2O3S
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
Physical Properties:
Orange-red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$60.00
25 mg$240.00

EPAC 5376753 (302826-61-5) is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2

References/Citations:

1) Brown et al. (2014), Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors; J. Biol. Chem., 289 29148
2) Parnell et al. (2015), The future of EPAC-targeted therapies: agonism versus antagonism; Trends Pharmacol. Sci., 36 203

Catalog Number:
10-1564
Activity:
EPAC inhibitor
Chemical Name:
5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Molecular Weight:
367.21
Molecular Formula:
C15H8Cl2N2O3S
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
Physical Properties:
Orange-red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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