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Epalrestat | Aldose reductase inhibitor

Epalrestat (82159-09-9) is an aldose reductase inhibitor (IC50 = 10 nM (rat lens) and 25 nM (human placenta).1,2 It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. Epalrestat may be used to prevent or slow the progression of diabetic neuropathy.3

References/Citations
1) Kikkawa et al. (1983) Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica, 24 290
2) Terashima et al. (1984) Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther., 229 226
3) Ramirez and Borja (2008) Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy, 28 646

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Catalog#  10-4423

$50.00
Quantity
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CAS:
82159-09-9
Catalog Number:
10-4423
Activity:
Aldose reductase inhibitor
Alternate Names:
ONO-2235
Chemical Name:
2-[(5Z)-5-[(E)-3-Phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic acid
Molecular Weight:
319.4
Molecular Formula:
C15H13NO3S2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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