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Product Details

EPPTB | TAAR1 antagonist

EPPTB (1110781-88-8) is a novel selective trace amine associated receptor 1 (TAAR1) antagonist (IC50=28 nM at mouse TAAR1).1,2 A useful tool for probing the physiologic role of TAAR1.3-6

1) Bradaia et al. (2009), The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system; Proc. Natl. Acad. Sci. USA, 106 20081
2) Stalder et al. (2011), Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773); Bioorg. Med. Chem. Lett., 21 1227
3) Zhang et al. (2018), Striatal Tyrosine Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine; Front. Pharmacol., 9 166
4) De Greggrio et al. (2016), The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors; Pharmacol. Res., 113 81
5) Cichero et al. (2014), Further insights into the phamracology of the human trace amine-associated receptors: discovery of the novel ligands for TAAR1 by a virtual screening approach; Chem. Biol. Drug Des., 84 712
6) Liu et al. (2014), Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1; J. Pharmacol. Exp. Ther. 350 124

Focus Biomolecules cell signaling reagent supplier, chemical structure of EPPTB | TAAR1 antagonist | CAS 1110781-88-8

Catalog#  10-1199

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Catalog Number:
TAAR1 antagonist
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
99% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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