Etrumadenant | Dual A2AR/A2BR antagonist

CAS:
 2239273-34-6
Catalog Number:
 10-4091

Available Options

Size:PriceQuantity 
5 mg$115.00
25 mg$395.00
Request Quote / Bulk / Custom Size
Product Inquiry

Etrumadenant (2239273-34-6) is a potent dual adenosine receptor antagonist (Ki: A2AR = 1.5 nM; A2BR = 2.0 nM)1.2  It blocked immunosuppressive signaling and increased cytokine secretion and proliferation in CAR T cells.3 Etrumadenant acted synergistically with epirubicin and a nanomedicine formulation to reverse adenosine-mediated immunosuppression in a triple negative breast cancer model.4

References/Citations:

  1. Jun et al. (2025), Discovery of Novel Triple A1/A2A/A2B Adenosine Receptor Antagonists for Cancer Immunotherapy; J. Med. Chem. 68 23117
  2. Seitz et al. (2019), Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers; Invest. New Drugs 37 711
  3. Seifert et al. (2022), Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant in CAR T cell function; Br. J Cancer 127 2175
  4. Cheng et al. (2025), Reversing adenosine-mediated immunosuppression in triple-negative breast cancer by synergistic chemo-immunotherapy via stimuli-responsive nanomedicines; eBioMedicine 125 106059
2239273-34-6, AB928, AB928 supplier, Dual A2AR/A2BR antagonist, Dual A2AR/A2BR inhibitor, Etrumadenant, Etrumadenant supplier
CAS:
2239273-34-6
Catalog Number:
10-4091
Activity:
Dual A2AR/A2BR antagonist
Chemical Names:
3-[2-amino-6-[1-[[6-(2-hydroxypropan-2-yl)-2-pyridinyl]methyl]triazol-4-yl]pyrimidin-4-yl]-2-methylbenzonitrile
Alternate Name:
AB928
Molecular Weight:
426.48
Molecular Formula:

C23H22N8O

Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
Tan solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Etrumadenant (2239273-34-6) is a potent dual adenosine receptor antagonist (Ki: A2AR = 1.5 nM; A2BR = 2.0 nM)1.2  It blocked immunosuppressive signaling and increased cytokine secretion and proliferation in CAR T cells.3 Etrumadenant acted synergistically with epirubicin and a nanomedicine formulation to reverse adenosine-mediated immunosuppression in a triple negative breast cancer model.4

References/Citations:

  1. Jun et al. (2025), Discovery of Novel Triple A1/A2A/A2B Adenosine Receptor Antagonists for Cancer Immunotherapy; J. Med. Chem. 68 23117
  2. Seitz et al. (2019), Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers; Invest. New Drugs 37 711
  3. Seifert et al. (2022), Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant in CAR T cell function; Br. J Cancer 127 2175
  4. Cheng et al. (2025), Reversing adenosine-mediated immunosuppression in triple-negative breast cancer by synergistic chemo-immunotherapy via stimuli-responsive nanomedicines; eBioMedicine 125 106059

STEM CELL

BOGO