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Fasentin | Glucose uptake inhibitor

Fasentin (392721-37-8) is a novel inhibitor of glucose uptake which acts via inhibition of the glucose transporter GluT1 and GluT4 (IC50=68 μM).1 Inhibition of glucose uptake is cell type specific2 and is a promising approach to new cancer therapeutics3. Rescues cardiac progenitor cell dysfunction and mitochondrial fission induced by high glucose.4 Sensitizes cells to FAS-induced cell death.5,6

References/Citations
1) Granchi et al. (2016), Anticancer agents interacting with membrane glucose transporters; Med. Chem. Comm., 7 1716
2) Kraus et al. (2018), Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell. Oncol. (Dordr), 41 485
3) Adekola et al. (2012), Glucose transporters in cancer metabolism; Curr. Opin. Oncol., 24 650
4) Choi et al. (2016), High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker; Prog. Biomol. Ther. (Seoul), 24 363
5) Schimmer et al. (2006), Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors; Cancer Res., 66 2367
6) Wood et al. (2008), A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death; Mol. Cancer Ther., 7 3546

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Catalog#  10-3730-0005

$55.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
392721-37-8
Catalog Number:
10-3730
Activity:
Glucose uptake inhibitor
Chemical Name:
N-[-4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
Molecular Weight:
279.64
Molecular Formula:
C11H9ClF3NO2
Solubility:
Soluble in DMSO (up to 28 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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