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Fasnall HCl | Fatty acid synthase inhibitor

Fasnall (CAS 929978-58-5) is a potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model1. Reduces HIV-1 virion production by 90% (EC50=213 nM).2


1) Alwarawrah et al. (2016) Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer, Cell Chem. Biol., 23 678
2) Kulkarni et al. (2017), Cellular fatty acid synthase is required for late stages of HIV-1 replication; Retrovirology, 14 45

Focus Biomolecules cell signaling supplier, chemical structure Fasnall HCl | Fatty acid synthase inhibitor | CAS 929978-58-5

Catalog#  10-1613-0005

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Catalog Number:
Fatty acid synthase inhibitor
Chemical Name:
5,6-Dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]thieno[2,3-d]pyrimidin-4-amine benzenesulfonate hydrochloride
Molecular Weight:
Molecular Formula:
C19H22N4S • HCl
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml)
Physical Properties:
Pale yellow solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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