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Product Details

Fatostatin | SREBP activation inhibitor

Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose and hepatic fat accumulation in obese ob/ob mice.1 Inhibits high glucose-induced TGF-β in mesangial cells.2 Cell permeable.

References/Citations
1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882
2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329

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Fatostatin | 125256-00-0 | Structure | Supplier

Catalog#  10-1355

$50.00
Quantity
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CAS:
125256-00-0
Catalog Number:
10-1355
Activity:
SREBP activation inhibitor
Chemical Name:
2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole
Molecular Weight:
294.42
Molecular Formula:
C18H18N2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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