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Favipiravir | Inhibitor of viral RNA-dependent RNA polymerase

Favipiravir is an inhibitor of Influenza viruses A, B, and C (IC50’s: A = 0.03-0.20 µg/mL H1N1, 0.01-0.30 H2N2, 0.08-0.48 H3N2, 0.14-0.15 H4N2, 0.24-1.60 H7N2, 0.20-0.82 H5N1, 0.35 H1N2; B = 0.04-0.09 µg/mL; C = 0.03-0.06 µg/mL) as well as strains resistant to adamantane-type antivirals, oseltamivir, and zanamivir.1,2,3 It displayed no cytotoxicity in a variety of cells. Favipiravir selectively inhibits viral RNA-dependent RNA polymerase.4 Favipiravir has also shown activity against other viruses including arena, phlebo, hanta, flavi, entero, alpha, respiratory syncytial, and noroviruses.5 In clinical trials for treatment of SARS-CoV-2.6,7

References/Citations
1) Furuta et al. (2002), In Vitro and In Vivo Activities of Anti-Influenza Virus Compound T-705; Antimicrob. Agents Chemother., 46 977
2) Takahashi et al. (2003) In Vitro and In Vivo Activities of T-705 and Oseltamivir Against Influenza Virus; Antivir. Chem. Chemother., 14 235
3) Sleeman et al. (2010) In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses; Antimicrob. Agents Chemother., 54 2517
4) Furuta et al. (2005) Mechanism of action of T-705 against influenza virus; Antimicrob. Agents Chemother., 49 981

5) Furuta et al. (2013) ), Favipiravir (T-705), a Novel Viral RNA Polymerase Inhibitor; Antiviral Res., 100 446
6) Dong et al. (2020) Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19); Drug Discov. Ther., 14 58
7) Tu et al. (2020) A Review of SARS-CoV-2 and the Ongoing Clinical Trials; Int.J.Mol.Sci., 21 E2657

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Favipiravir | Inhibitor of viral RNA-dependent RNA polymerase | CAS 259793-96-9

Catalog#  10-4471-0005

$45.00
Quantity
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CAS:
259793-96-9
Catalog Number:
10-4471
Activity:
Inhibitor of viral RNA-dependent RNA polymerase
Chemical Name:
6-Fluoro-3-hydroxypyrazine-2-carboxamide
Alternate Name:
T-705
Molecular Weight:
157.10
Molecular Formula:
C5H4FN3O2
Solubility:
Soluble in DMSO (30 mg/mL), water (12 mg/mL with warming)
Physical Properties:
Off-white solid
Purity:
>99% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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