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Felodipine | L-type Ca channel blocker

Felodipine (72509-76-3) is a potent L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels.1,2 It displays high vascular selectivity over cardiac muscle, thus lowering arterial blood pressure without altering cardiac contractility. Felodipine is used in the clinic as an antihypertensive agent.

References/Citations
1) Todd and Faulds, (1992) Felodipine. A review of the pharmacology and therapeutic useof the extended release formulation in cardiovascular disorders; Drugs 44 251
2) Furukawa et al. (1999) Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther. 291 464

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Focus Biomolecules supplier, chemical structure of Felodipine | L-type Ca channel blocker | CAS 72509-76-3

Catalog#  10-2020

$56.00
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CAS:
72509-76-3
Catalog Number:
10-2020
Activity:
L-type Ca channel blocker
Chemical Name:
3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Molecular Weight:
384.25
Molecular Formula:
C18H19Cl2NO4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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