Felodipine | L-type Ca channel blocker

Felodipine (72509-76-3) is a potent L-type Ca²⁺ channel blocker that is selective over N-, R-, P/Q- and T-type channels.^1,2 It displays high vascular selectivity over cardiac muscle, thus lowering arterial blood pressure without altering cardiac contractility. Felodipine is used in the clinic as an antihypertensive agent.

References/Citations
1) Todd and Faulds, (1992) Felodipine. A review of the pharmacology and therapeutic useof the extended release formulation in cardiovascular disorders; Drugs 44 251
2) Furukawa et al. (1999) Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther. 291 464