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Product Details

Filipin III | Cholesterol probe

Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used for staining.2 Disrupts the lipid raft/caveolae endocytosis pathway.3 Prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.4

References/Citations

1) Smejkal and Hof (1994), Cholesterol-specific probe for lipoproteins immobilized on nitrocellulose membranes; Biotechniques, 16 68
2) Bornig and Geyer  (1974), Staining of cholesterol with the fluorescent antibiotic “filipin”; Acta Histochemica, 50 110
3) Huo et al. (2003), Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction; J. Biol. Chem., 278 11561
4) Marella et al. (2002), Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release; J. Biol. Chem., 277 25457

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Filipin III | 480-49-9 | Structure | Supplier

Catalog#  10-1490-0001

$120.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
480-49-9
Catalog Number:
10-1490
Activity:
Cholesterol probe
Source:
Isolated from Streptomyces filipinensis
Molecular Weight:
654.85
Molecular Formula:
C35H58O11
Solubility:
Soluble in Methanol (up to 10 mg/ml)
Physical Properties:
White or light yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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