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Flecainide acetate | Sodium channel blocker

Flecainide acetate (54143-56-5) is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4


1) Rouet and Ducouret (1994), Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle; J. Cardiovasc. Pharmacol., 24 177
2) Singh et al. (1984), The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions; Ann. N.Y. Acad. Sci., 432 210
3) Banitt et al. (1977), Anti-arrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides; J. Med. Chem., 20 821
4) Melgari et al. (2015), Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide; J. Mol. Cell. Cardiol., 86 42

Focus Biomolecules cell signaling supplier, chemical structure Flecainide acetate | Sodium channel blocker | CAS 54143-56-5

Catalog#  10-2992-0010

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Catalog Number:
Sodium channel blocker
Chemical Name:
N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
Molecular Weight:
Molecular Formula:
C17H20F6N3O3 • C2H4O2
Soluble in DMSO (up to 45 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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