Florfenicol | Broad-spectrum antibiotic

CAS:
 73231-34-2
Catalog Number:
 10-3038
Florfenicol chemical structure

Available Options

Size:PriceQuantity 
1 g$55.00
5 g$195.00
Request Quote / Bulk / Custom Size
Product Inquiry

Florfenicol (73231-34-2) is a fluoro-analog of thiamphenicol and is a broad-spectrum antibiotic1,2 which is widely used in animal health3. It interferes with bacterial protein synthesis by binding to the 50S subunit of the70S ribosome.4 Extensive use in aquaculture, livestock and poultry farming has led to an increase in bacterial antibiotic resistance and facilitated the spread of resistance genes.4 Suppresses LPS-stimulated splenocyte proliferation and impairs immune responses in mice.5

References/Citations:

  1. Syriopoulou et al. (1981), In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol;  J. Antimicrob. Chemother., 19 294
  2. Cannon et al. (1990), A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives; J. Antimicrob. Chemother., 26 307
  3. Shen et al. (2002), Pharmacokinetics of florfenicol in healthy and Escherichia coli-infected broiler chickens; Res. Vet. Sci., 73 137
  4. Guo et al. (2024), A review on the antibiotic florfenicol: Occurrence, environmental fate, effects, and health risks; Environ. Res., 244 117934
  5. Shuang et al. (2011), Immunosuppressive Activity of Florfenicol on the Immune Responses in Mice; Immunol. Invest., 40 356
73231-34-2, florfenicol, Florfenicol supplier
CAS:
73231-34-2
Catalog Number:
10-3038
Activity:
Broad-spectrum antibiotic
Chemical Names:
2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]-acetamide
Alternate Name:
SCH-25298
Molecular Weight:
358.21
Molecular Formula:

C12H14Cl2FNO6S

Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
Room temperature
Stability:
Stable for up to 2 years when stored as supplied @ room temperature. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Florfenicol (73231-34-2) is a fluoro-analog of thiamphenicol and is a broad-spectrum antibiotic1,2 which is widely used in animal health3. It interferes with bacterial protein synthesis by binding to the 50S subunit of the70S ribosome.4 Extensive use in aquaculture, livestock and poultry farming has led to an increase in bacterial antibiotic resistance and facilitated the spread of resistance genes.4 Suppresses LPS-stimulated splenocyte proliferation and impairs immune responses in mice.5

References/Citations:

  1. Syriopoulou et al. (1981), In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol;  J. Antimicrob. Chemother., 19 294
  2. Cannon et al. (1990), A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives; J. Antimicrob. Chemother., 26 307
  3. Shen et al. (2002), Pharmacokinetics of florfenicol in healthy and Escherichia coli-infected broiler chickens; Res. Vet. Sci., 73 137
  4. Guo et al. (2024), A review on the antibiotic florfenicol: Occurrence, environmental fate, effects, and health risks; Environ. Res., 244 117934
  5. Shuang et al. (2011), Immunosuppressive Activity of Florfenicol on the Immune Responses in Mice; Immunol. Invest., 40 356

STEM CELL

BOGO