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Fluoxetine HCl | Serotonin reuptake inhibitor

Fluoxetine HCl (56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (Kd=0.81 nM) over the norepinephrine (Kd=240 nM) and dopamine (Kd=3.6 mM) transporters.1 A clinically useful antidepressive agent.2 Has shown some potential in autism spectrum disorders.3 Attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage.4 Orally active and active in vivo. Increases proliferation of neuronal precursors derived from human embryonic stem cells, inducing differentiation and strongly enhancing neuronal characteristics.5


1) Tatsumi et al. (1997), Pharmacological profile of antidepressants and related compounds at human monoamine transporters; Eur. J. Pharmacol., 340 249
2) Benfield et al. (1986), Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness; Drugs, 32 481
3) Benvenuto et al. (2013), Pharmacotherapy of autism spectrum disorders; Brain Dev., 35 119
4) Liu et al. (2018), Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NFkB signaling pathway; J. Neuroinflammation, 15 347
5) Chang et al. (2010), Increased cellular turnover in response to fluoxetine in neurona precursors derived from human embryonic stem cells; Prog. Int. J. Dev. Biol., 54 707

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Catalog#  10-2728-0100

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Catalog Number:
Serotonin reuptake inhibitor
Chemical Name:
(±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride
Alternate Names:
Molecular Weight:
Molecular Formula:
C17H18F3NO • HCl
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 4 mg/ml)
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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