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Formononetin | PPARgamma activator; increases adipocyte thermogenesis

Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1 Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2 Accelerates wound repair by increasing expression of Egr-1 transcription factor.3 Potential cancer chemopreventive and chemotherapeutic.4 Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5

1) Nie et al. (2018), The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol., 175 1439
2) Gautam et al. (2017), Formononetin, an isoflavone, activates AMO-activated protein kinase/ßβ-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit., 117 645
3) Huh et al. (2011), Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol., 11 46
4) Ong et al. (2019), Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel), 11 E611
5) Li et al. (2018), Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother., 106 349


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Catalog#  10-2252-0020

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Catalog Number:
PPARγ activator; increases adipocyte thermogenesis
Chemical Name:
Alternate Name:
7-Hydroxy-4'-methoxyisoflavone; Biochanin B; Neochanin; NSC 93360; Formononetol
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 100 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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