Formoterol hemifumarate | ß2 adrenergic agonist

CAS:
43229-80-7
Catalog Number:
10-5092
Activity:
Potent and selective β2 adrenergic agonist
Chemical Name:
(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide
Molecular Weight:
402.44
Molecular Formula:
C19H24N2O4·1/2C4H4O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$68.00
50 mg$200.00

Formoterol hemifumarate (43229-80-7) is a potent, long-acting agonist specific to β2 (Ki = 7.6 nM), but not β1 (Ki > 2.6 µM), adrenergic receptors in trachea (pD2 = 9.3) over atrium (pD2 = 7.0).1,2 Reduces adhesion and superoxide anion production in cultured activated eosinophils.3 Reverses cachexia in rats and mice via inhibition of the ATP-ubiquitin-dependent proteolytic system.4 Rescues LPS-induced motor function deficits and nigrostriatal dopamine loss in a rat model of Parkinson’s.5 Clinically useful for respiratory diseases.

References:

1) Anderson et al. (1993), Formoterol: pharmacology, molecular basis of agonism and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator; Life Sciences, 52 2145
2) Teng et al. (2005), Structure-activity relationship study of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett., 15 5039
3) Noguchi et al. (2015), Effect of beta2-adrenergic agonist on eosinophil adhesion, superoxide anion generation, and degranulation; Allergol. Int., 64 S46
4)Busquets et al. (2004), Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting; Cancer Res., 64 6725
5) O’Neill et al. (2020), Pharmacological targeting of ß2-adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson’s disease; Br. J. Pharmacol., 177 282

CAS:
43229-80-7
Catalog Number:
10-5092
Activity:
Potent and selective β2 adrenergic agonist
Chemical Name:
(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide
Molecular Weight:
402.44
Molecular Formula:
C19H24N2O4·1/2C4H4O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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