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Product Details

FSC-231 | PICK1 PDZ domain inhibitor

FSC-231 is the first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1). Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 µM). Does not bind to PDZ domains of postsynaptic density protein 95 (PSD-95) nor glutamate receptor interacting protein 1 (GRIP1).  Pretreatment of cultured hippocampal neurons inhibits coimmunoprecipitation of the AMPA receptor GluR2 subunit with PICK1. FSC231 accelerated recycling of fluorophore-tagged GluR2 in hippocampal neurons after internalization in response to NMDA receptor activation. Blocks the expression of both long-term depression and long-term potentiation.1,2 Attenuates cocaine seeking in a rodent model.3 Blocks PICK1-induced anti-inflammatory effect in acute liver injury.4


1) Thorsen et al. (2010), Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD; Proc. Natl. Acad. Sci. USA, 107 413
2) Tang et al. (2013), Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia; Behav. Brain Res., 256 481
3) Schmidt et al. (2013), Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma; J. Neuroscience, 33 14160
4) Xie et al. (2016), PICK1 confers anti-inflammatory effects in acute liver injury via suppressing M1 macrophage polarization; Biochemie, 127 121

Focus Biomolecules cell signaling supplier, chemical structure of FSC-231 | PICK1 PDZ domain inhibitor | CAS 1215849-96-9

Catalog#  10-1406-0005

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Catalog Number:
PICK1 PDZ domain inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 35 mg/ml with warming) or in Ethanol (up to 18 mg/ml with warming)
Physical Properties:
Yellow solid
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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