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FTY720 HCl | Sphingosine-1-phosphate receptor agonist

FTY720 HCl (162359-56-0) is an analog of sphingosine (Cat.# 10-2287) which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3).1 Potently inhibits regulatory T cell proliferation in vitro and in vivo.2 FTY720 HCl enhances microvascular remodeling via expansion of arterioles and capillary networks.3 Clinically useful multiple sclerosis drug.  Potent immunomodulator.

1) Brinkmann et al. (2002), The immune modulator FTY720 targets spingosine-1-phosphate receptors; J. Biol. Chem., 277 21453
2) Wolf et al. (2009), The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo; J. Immunol., 183 3751
3) Awojoodu et al. (2013), Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis; Proc. Natl. Acad. Sci. USA, 110 13785
4) Chiba (2005), FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors; Pharmacol. Ther., 108 308 

Focus Biomolecules supplier, chemical structure of FTY720 HCl | Sphingosine-1-phosphate receptor agonist | CAS 162359-56-0

Catalog#  10-2138-0050

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Catalog Number:
Sphingosine-1-phosphate receptor agonist
Alternate Names:
Chemical Name:
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride
Molecular Weight:
Molecular Formula:
C19H33NO2 HCl
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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