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Fumagillin | MetAP-2 inhibitor

Fumagillin (23110-15-8) is a natural product isolated from the microbial organism Aspergillus fumigatus and used as an antimicrobial for honey bees. It covalently binds and inhibits methionine aminopeptidase-2.1 Fumagillin also inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo.2

References/Citations
1) Sin et al. (1997) The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2; Proc. Natl. Acad. Sci. USA, 94 6099
2) Ingber et al. (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth; Nature, 348 555

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Focus Biomolecules cell signaling reagent supplier, chemical structure Fumagillin | MetAP-2 inhibitor | CAS 23110-15-8

Catalog#  10-1146

$75.00
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CAS:
23110-15-8
Catalog Number:
10-1146
Activity:
MetAP-2 inhibitor
Chemical Name:
(2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Molecular Weight:
458.54
Molecular Formula:
C26H34>/sub>O7
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Orange solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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