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Gabapentin | Neuropathic pain drug

Gabapentin (60142-96-3) is an approved drug for treatment of various types of neuropathic pain and some forms of epilepsy.  The mechanism of action of gabapentin is not well understood. Despite being a structural mimic of GABA, it does not bind to GABA receptors at concentrations up to 1 mM.1,2 Some of its actions may be due to disrupting calcium channels.3

References/Citations

1) Cheng et al. (2004), Does gabapentin act as an agonist at native GABA(B) receptors?; J. Biomed. Sci., 11 346
2) Lanneau et al. (2001), Gabapentin is not a GABAB receptor agonist; Neuropharmacology 41 965
3) Hendrich et al. (2008), Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin; Proc. Natl. Acad. Sci. USA, 105 3628

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Focus Biomolecules cell signaling reagent supplier, chemical structure Gabapentin | Neuropathic pain drug | CAS 60142-96-3

Catalog#  10-2042-0025

$40.00
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CAS:
60142-96-3
Catalog Number:
10-2042
Activity:
Neuropathic pain drug
Chemical Name:
1-(Aminomethyl)cyclohexane
Alternate Names:
Neurontin
Molecular Weight:
171.24
Molecular Formula:
C9H17NO2
Solubility:
Soluble in Water (up to XX10g/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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