Galanthamine HBr | Acetylcholinesterase inhibitor

CAS:
17991
Catalog Number:
10-1136
Activity:
Acetylcholinesterase inhibitor
Chemical Name:
4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, hydrobromide
Molecular Weight:
368.27
Molecular Formula:
C17H21NO3 HBr
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Water (up to 12 mg/ml).
Physical Properties:
Lyophillized solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

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20 mg$40.00
100 mg$160.00

Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM.1 Allosteric potentiator at neuronal nicotinic ACh receptors.2 Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells.3 Galanthamine HBr is a clinically useful agent for symptomatic relief of Alzheimer’s disease but fails to prevent progression of the disease.4,5

References/Citations:

1) Racchi et al. (2004), Acetylcholinesterase inhibitors: novel activities of old molecules; Pharmacol. Res., 50 441
2) Samochocki et al. (2003), Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors; J. Pharmacol. Exp. Ther., 305 1024
3) Arias et al. (2004), Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors; Neuropharmacology, 46 103
4) Rockwood et al. (2001), Effects of a flexible galantamine dose in Alzheimer’s disease: a randomized, controlled trial; J. Neurol. Neurosurg. Psychiatry, 71 589
5) Chen et al. (2007), Current experimental therapy for Alzheimer’s disease; Curr. Neuropharmacol., 5 127

CAS:
17991
Catalog Number:
10-1136
Activity:
Acetylcholinesterase inhibitor
Chemical Name:
4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, hydrobromide
Molecular Weight:
368.27
Molecular Formula:
C17H21NO3 HBr
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Water (up to 12 mg/ml).
Physical Properties:
Lyophillized solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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