Galanthamine HBr | Acetylcholinesterase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $40.00 | ||
| 100 mg | $160.00 |
Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM.1 Allosteric potentiator at neuronal nicotinic ACh receptors.2 Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells.3 Galanthamine HBr is a clinically useful agent for symptomatic relief of Alzheimer’s disease but fails to prevent progression of the disease.4,5
References/Citations:
1) Racchi et al. (2004), Acetylcholinesterase inhibitors: novel activities of old molecules; Pharmacol. Res., 50 441
2) Samochocki et al. (2003), Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors; J. Pharmacol. Exp. Ther., 305 1024
3) Arias et al. (2004), Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors; Neuropharmacology, 46 103
4) Rockwood et al. (2001), Effects of a flexible galantamine dose in Alzheimer’s disease: a randomized, controlled trial; J. Neurol. Neurosurg. Psychiatry, 71 589
5) Chen et al. (2007), Current experimental therapy for Alzheimer’s disease; Curr. Neuropharmacol., 5 127
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM.1 Allosteric potentiator at neuronal nicotinic ACh receptors.2 Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells.3 Galanthamine HBr is a clinically useful agent for symptomatic relief of Alzheimer’s disease but fails to prevent progression of the disease.4,5
References/Citations:
1) Racchi et al. (2004), Acetylcholinesterase inhibitors: novel activities of old molecules; Pharmacol. Res., 50 441
2) Samochocki et al. (2003), Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors; J. Pharmacol. Exp. Ther., 305 1024
3) Arias et al. (2004), Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors; Neuropharmacology, 46 103
4) Rockwood et al. (2001), Effects of a flexible galantamine dose in Alzheimer’s disease: a randomized, controlled trial; J. Neurol. Neurosurg. Psychiatry, 71 589
5) Chen et al. (2007), Current experimental therapy for Alzheimer’s disease; Curr. Neuropharmacol., 5 127
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