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gamma-L-Glutamyl-p-nitroanilide HCl | L-Glutamine uptake inhibitor and gamma-glutamyl transpeptidase substrate

L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5)2. Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3

References/Citations
1) Meister et al. (1981), γ-Glutamyl transpeptidase; Methods Enzymol., 77 237
2) Esslinger et al. (2005), N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem., 13 1111
3) Nicklin et al. (2012), Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell, 136 521

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Focus Biomolecules cell signaling reagent supplier, chemical structure of L-Glutamyl γ-(p-nitroanilide) HCl | CAS 67953-08-6

Catalog#  10-4568

$20.00
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CAS:
67953-08-6
Catalog Number:
10-4568
Activity:
L-Glutamine uptake inhibitor and gamma-glutamyl transpeptidase substrate
Alternate Names:
GPNA
Molecular Weight:
303.7
Molecular Formula:
C11H13N3O5 HCl
Solubility:
Soluble in Water (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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