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GBR-12909 2HCl | Dopamine reuptake inhibitor

GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma receptor ligand.2 Very fast acting via i.v. administration.3

References/Citations
1) Andersen et al. (1989), The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action; Eur. J. Pharmacol., 166 493
2) Contreras et al. (1990), GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain; Life Sci., 47 PL133
3) Yorgason et al. (2011), Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection; Neuroscience, 182 125

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Focus Biomolecules supplier, chemical structure of GBR-12909 2HCl | Dopamine reuptake inhibitor | CAS 67469-78-7

Catalog#  10-1458

$60.00
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CAS:
67469-78-7
Catalog Number:
10-1458
Activity:
Dopamine reuptake inhibitor
Chemical Name:
1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Molecular Weight:
523.5
Molecular Formula:
C28H32F2N2O 2HCl
Solubility:
Soluble in DMSO (up to 30 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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