my account
Login
  Loading... Please wait...

Product Details

GDC-0941 | pan-PI3K inhibitor

GDC-0941 (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM.1,2   GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s.3 Currently in clinical trials.4

References/Citations

1) Folkes et al. (2008), The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine(GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer;  J. Med. Chem., 51 5522
2) Raynaud et al. (2009), Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinase: from PI-103 through PI-540, PI620 to the oral agent GDC-0941; Mol. Cancer Ther., 8 1725
3) Knapp et al. (2013), A public-private partnership to unlock the untargeted kinome; Nat. Chem. Biol., 9 3
4) Sarker et al. (2015), First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors; Clin. Cancer Res., 21 77

swipe
Focus Biomolecules cell signaling reagent supplier, chemical structure of GDC-0941 | pan-PI3K inhibitor | CAS 957054-30-7

Catalog#  10-2141

$58.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
957054-30-7
Catalog Number:
10-2141
Activity:
pan-PI3K inhibitor
Molecular Weight:
513.64
Molecular Formula:
C23H27N7O3S2
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the GDC-0941 | pan-PI3K inhibitor to your wish list.