Gefitinib (184475-35-2) is a potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM)1. Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo2. Enhances efficacy of cytotoxic agents3. Inhibits growth factor production and angiogenesis4. Clinically useful anticancer agent.
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4) Ciaradiello et al. (2001), Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor; Clin. Cancer Res., 7 1459