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Geldanamycin-FITC | HSP90 fluorescent probe

Geldanamycin-FITC is a novel geldanamycin fluorescent probe1 that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3 May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy.4


1) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90;  Bioorg. Med. Chem. Lett., 13 3975
2) Kim et al. (2004), Development of a fluorescent polarization assay for the molecular chaperone Hsp90;  J. Biomol. Screen., 9 375
3) Austin et al. (2012), Fragment screening using capillary electrophoresis (Defrag) for hit identification of heat shock protein 90 ATPase inhibitors;  J. Biomol. Screen., 17 868
4) Gooljarsingh et al. (2006), A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues;  Proc. Natl. Acad. Sci. USA, 103 7625

Focus Biomolecules cell signaling reagent supplier, chemical structure of Geldanamycin-FITC | HSP90 fluorescent probe

Catalog#  10-1289-0001

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
HSP90 fluorescent probe
Alternate Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (greater than 10 mg/ml)
Physical Properties:
Purple solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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