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Gimeracil | Dihydropyrimidine dehydrogenase inhibitor

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).  Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2  Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

References/Citations

1) Diasio (1999) Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park), 13 17
2) Kobayakawa and Kojima (2011), Tegafur/giimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther., 4 193
3) Sakata et al. (2011), Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci., 102 1712

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Catalog#  10-4601

$50.00
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CAS:
103766-25-2
Catalog Number:
10-4601
Activity:
Dihydropyrimidine dehydrogenase inhibitor
Chemical Name:
5-Chloro-4-hydroxypyridine-2(1H)-one
Molecular Weight:
145.54
Molecular Formula:
C5H4ClNO2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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