my account
Login
  Loading... Please wait...

Product Details

Retinoic acid | Retinoid RAR agonist

all-trans-Retinoic acid (302-79-4) a metabolite of Vitamin A, is an endogenous ligand for the retinoic acid receptor (RAR). The binding of retinoic acid to the RAR and retinoid X (RXR) heterodimer causes conformation changes in RAR that affects the binding of other proteins that regulate the growth and differentiation of a variety of both normal and malignant cells.1 Retinoic acid promotes differentiation of embryonic stem cells (ESCs) into a variety of cell types in vitro.2-4

References/Citations
1) Allenby (1993), Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acid; Proc. Natl. Acad. Sci. USA, 90 30
2) Dani et . (1997) Differentiation of embryonic stem cells into adipocytes in vitro; J. Cell Sci. 110 1279
3) Hu (2009) Differentiation Of Spinal Motor Neurons From Pluripotent Human Stem Cells; Nat. Protoc., 4 1295
4) Sasai (2002) Generation of dopaminergic neurons from embryonic stem cells J. Neurol., 249 II 41

swipe
Retinoic acid | 302-79-4 | Structure | Supplier

Catalog#  10-1138

$22.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
302-79-4
Catalog Number:
10-1138
Activity:
Retinoid RAR agonist
Alternate Names:
ATRA
Chemical Name:
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid
Molecular Weight:
300.44
Molecular Formula:
C20H28O2
Solubility:
Soluble in DMSO (up to 8 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Yellow solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Retinoic acid | Retinoid RAR agonist to your wish list.