Gliocidin | Nicotinamide-mimetic prodrug

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Gliocidin (62289-81-0) is a nicotinamide-mimetic prodrug that targets de novo purine biosynthesis vulnerability in glioblastoma (IC50 = 150 nM).1  Gliocidin was converted via the NAD+ salvage pathway to gliocidin-adenine dinucleotide with directly interfered with the activity of IMPDH2 resulting in guanylate depletion and cell death.  Displays strong blood brain barrier permeability and suppression of glioblastoma in athymic nude mice.  Gliocidin showed synergistic effects with temozolomide.  Inhibitor of the SARS 3CLPRO protease.2

References/CItations:

  1. Chen et al. (2024), Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma; Nature 636 466
  2. Zhang et al. (2007), Design, Synthesis, and Evaluation of Inhibitors for Severe Acute Respiratory Syndrome 3C-Like Protease Based on Phthalhydrazide Ketones or Heteroaromatic Esters; J. Med. Chem. 50 1850
62289-81-0, anti-glioblastoma, Gliocidin, Gliocidin supplier, guanine biosynthesis inhibitor, nicotinamide prodrug, nicotinamide-mimetic, Purine biosynthesis inhibitor, SW106065
Alternate Name:
SW106065

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Gliocidin (62289-81-0) is a nicotinamide-mimetic prodrug that targets de novo purine biosynthesis vulnerability in glioblastoma (IC50 = 150 nM).1  Gliocidin was converted via the NAD+ salvage pathway to gliocidin-adenine dinucleotide with directly interfered with the activity of IMPDH2 resulting in guanylate depletion and cell death.  Displays strong blood brain barrier permeability and suppression of glioblastoma in athymic nude mice.  Gliocidin showed synergistic effects with temozolomide.  Inhibitor of the SARS 3CLPRO protease.2

References/CItations:

  1. Chen et al. (2024), Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma; Nature 636 466
  2. Zhang et al. (2007), Design, Synthesis, and Evaluation of Inhibitors for Severe Acute Respiratory Syndrome 3C-Like Protease Based on Phthalhydrazide Ketones or Heteroaromatic Esters; J. Med. Chem. 50 1850