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Product Details

Glyburide | K-ATP channel blocker

Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1 Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Glyburide also inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.2 Cell permeable.

References/Citations
1) Brogden et al. (1979), Glipizide: a review of its pharmacological properties and therapeutic use; Drugs, 18 329
2) Sheppard and Welsh (1992), Effect of ATP-sensitive K+ channel regulators on cystic fibrose transmembrane conductance regulator chloride currents; J. Gen. Physiol., 100 573

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Glyburide | 10238-21-8 | Structure | Supplier

Catalog#  10-1325

$30.00
Quantity
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CAS:
10238-21-8
Catalog Number:
10-1325
Activity:
K-ATP channel blocker
Alternate Names:
Glibenclamide
Chemical Name:
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]suphonyl]phenyl]ethyl]-2-methoxybenzamide
Molecular Weight:
494.01
Molecular Formula:
C23H28ClN3O5S
Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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