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Product Details

Go-6983 | PKC inhibitor

Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced HSP27 disassociation.2  Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4  

References/Citations

1) Gschwendt et al. (1996), Inhibition od protein kinas C mu by various inhibitors. Differentiation from protein kinas C isoenzymes; FEBS Lett., 392 77
2) Kato et al. (2001), Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27; Cell Stress Chaperones, 6 16
3) Rajendran et al. (2013), Inhibition of protein kinas C signaling maintains rat embryonic stem cell pluripotency; J. Biol. Chem., 288 24351
4) Young et al. (2005), Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury; Cardiovasc, Drug Rev., 23 255

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Go-6983 | PKC inhibitor | CAS 133053-19-7

Catalog#  10-2621-0001

$35.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
133053-19-7
Catalog Number:
10-2621
Activity:
PKC inhibitor
Chemical Name:
3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular Weight:
442.51
Molecular Formula:
C26H26N4O3
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Red-orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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