my account
  Loading... Please wait...

Product Details

GPI-16552 | PARG inhibitor

GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia2. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model3 and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma4. GPI-16552 synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells5.

1) Zhang et al. (2002), PARP and PARG as novel therapeutic targets; Drugs Future, 27 371
2) Lu et al. (2003), Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat; Brain Res., 978 99
3) Cuzzocrea et al. (2005), PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reprofusion; FASEB J., 19 558
4) Cuzzocrea et al. (2006), Poly(ADP-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord trauma; J. Pharmacol. Exp. Ther., 319 127
5) Tentori et al. (2005), Poly(ADP-roibose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide; Eur. J. Cancer, 41 2948

Focus Biomolecules cell signaling reagent supplier, chemical structure of GPI-16552 | PARG inhibitor | CAS 443794-40-9

Catalog#  10-1502

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
PARG inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Pale yellow solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the GPI-16552 | PARG inhibitor to your wish list.