Gramicidin A | Channel-forming ionophore

CAS:
 11029-61-1
Catalog Number:
 10-3556
Gramicidin A Chemical structure Focus

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Gramicidin A (11029-61-1) is a hydrophilic non-ribosomal peptide ionophore that forms channels in membranes which are monovalent cation-permeable.1,2 Disruption of cellular ionic homeostasis is the basis for its antibiotic activity.3 It is also cytotoxic to a variety of cancer cell lines4 and tumor xenografts5. Gramicidin A was shown to stimulate melanoma differentiation-associated protein 5 (MDA5)-mediated IFN signaling by enhancing its oligomerization onto RNA and thus represents a new tool to manipulate MDA5 activity.6

References/Citations:

  1. Kelkar and Chattopadhyay (2007), The gramicidin ion channel: A model membrane protein; Biochim. Biophys. Acta. 1768 2011
  2. Kondrashov et al. (2025), Adsorption of Bovine Serum Albumin to Lipid Membranes Increases the Number and Stability of Ion Channels of Gramicidin A; Langmuir 41 25992
  3. Mulukutla et al. (2024), Recent advances in antimicrobial peptide-based therapy; Bioorg. Chem. 145 107151
  4. Maham et al. (2025), Anticancer role of Gramicidin A in myeloid leukemia; Discov. Oncol. 16 1839
  5. David and Rajasekaran (2015), Gramicidin A: A New Mission for an Old Antibiotic; Kidney Cancer VHL 2 15
  6. Li et al. (2023), New role of gramicidin A in RIG-I-like receptors-mediated IFN signalling; Immunology 169 219
11029-61-1, Gramicidin A, Gramicidin A supplier, Peptide ionophore
CAS:
11029-61-1
Catalog Number:
10-3556
Activity:
Peptide ionophore
Chemical Names:
Peptide fermentation product isolated from B brevis
Molecular Weight:
1882.29
Molecular Formula:

C99H140N20O17

Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
White to off-white solid
Purity:

>95% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

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Gramicidin A (11029-61-1) is a hydrophilic non-ribosomal peptide ionophore that forms channels in membranes which are monovalent cation-permeable.1,2 Disruption of cellular ionic homeostasis is the basis for its antibiotic activity.3 It is also cytotoxic to a variety of cancer cell lines4 and tumor xenografts5. Gramicidin A was shown to stimulate melanoma differentiation-associated protein 5 (MDA5)-mediated IFN signaling by enhancing its oligomerization onto RNA and thus represents a new tool to manipulate MDA5 activity.6

References/Citations:

  1. Kelkar and Chattopadhyay (2007), The gramicidin ion channel: A model membrane protein; Biochim. Biophys. Acta. 1768 2011
  2. Kondrashov et al. (2025), Adsorption of Bovine Serum Albumin to Lipid Membranes Increases the Number and Stability of Ion Channels of Gramicidin A; Langmuir 41 25992
  3. Mulukutla et al. (2024), Recent advances in antimicrobial peptide-based therapy; Bioorg. Chem. 145 107151
  4. Maham et al. (2025), Anticancer role of Gramicidin A in myeloid leukemia; Discov. Oncol. 16 1839
  5. David and Rajasekaran (2015), Gramicidin A: A New Mission for an Old Antibiotic; Kidney Cancer VHL 2 15
  6. Li et al. (2023), New role of gramicidin A in RIG-I-like receptors-mediated IFN signalling; Immunology 169 219

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