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Product Details

GRI-977143 | LPA2 antagonist

GRI-977143 (325850-81-5) is a selective agonist of the lysophosphatidic acid-2 (LPA2) receptor. Displays antiapoptotic activity.1 Rescues apoptotically condemned cells from death and injury caused by high-dose γ-irradiation in vitro and in vivo. GRI-977143 rescues mice from deadly levels of radiation when given 24 hours post-exposure.2 Activates the ERK1/2 prosurvival pathway.2

References/Citations

1) Kiss et al. (2012), Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions; Mol. Pharmacol. 82 1162
2) Kiss et al. (2013), Mitigation of radiation injury by selective stimulation of the LPA2 receptor; Biochim. Biophys. Acta 1831 117

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Focus Biomolecules cell signaling reagent supplier, chemical structure of GRI-977143 | LPA2 antagonist | CAS 325850-80-5

Catalog#  10-1442-0005

$80.00
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CAS:
325850-80-5
Catalog Number:
10-1442
Activity:
LPA2 antagonist
Chemical Name:
2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
Molecular Weight:
391.44
Molecular Formula:
C22H17NO6S
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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