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GRL-0617 | Potent SARS-CoV PLpro inhibitor

GRL-0617 is a potent (IC50 = 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0617 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50 = 15 µM).  Inactive against human DUB-like proteases HAUSP, USP18, UCH-L1, UCH-L3, and PLP2

References/Citations

1)    Ratia et al. (2008), A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication; Proc. Natl. Acad. Sci. USA, 105 16119

2)    Ghosh et al. (2009), Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease; J. Med. Chem. 52 5228

Weight 1 mg
Dimensions 1 × 1 × 1 cm
Size:

5 mg, 25 mg

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CAS:
1093070-16-6
Catalog Number:
10-4965
Activity:
Potent SARS-CoV PLpro inhibitor
Chemical Name:
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
Molecular Weight:
304.39
Molecular Formula:
C20H20N2O
Solubility:
Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
Physical Properties:
Beige solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

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GRL-0617 | Potent SARS-CoV PLpro inhibitor

$90.00 – $325.00

CAS:
1093070-16-6
Catalog Number:
10-4965
Activity:
Potent SARS-CoV PLpro inhibitor
Chemical Name:
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
Molecular Weight:
304.39
Molecular Formula:
C20H20N2O
Solubility:
Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
Physical Properties:
Beige solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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Products GRL-0617 | Potent SARS-CoV PLpro inhibitor