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GSK-137647 | GPR120 agonist

GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively1. GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR1202.

References/Citations
1) Martin et al. (2012), Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res., 53 2256
2) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett., 24 3100

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Focus Biomolecules cell signaling reagent supplier, chemical structure of GSK-137647 | GPR120 agonist | CAS 349085-82-1

Catalog#  10-1516

$90.00
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CAS:
349085-82-1
Catalog Number:
10-1516
Activity:
GPR120 agonist
Chemical Name:
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Molecular Weight:
305.40+L302
Molecular Formula:
C16H19NO3S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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