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GSK-137647 | GPR120 agonist

CAS:
349085-82-1
Catalog Number:
10-1516
Activity:
GPR120 agonist
Chemical Name:
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Molecular Weight:
305.40+L302
Molecular Formula:
C16H19NO3S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2

References/Citations:

1) Martin et al. (2012), Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res., 53 2256
2) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett., 24 3100

GSK-137647 | GPR120 agonist is also available in the Cellular Metabolism Library.
CAS:
349085-82-1
Catalog Number:
10-1516
Activity:
GPR120 agonist
Chemical Name:
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Molecular Weight:
305.40+L302
Molecular Formula:
C16H19NO3S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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