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Product Details

GSK-690693 HCl | AKT inhibitor

GSK-690693 (937174-76-0) is a novel ATP-competitive pan-specific Akt kinase inhibitor. (IC50's=2, 13, 9 nM for Akt1, 2 and 3 respectively) Antitumor activity. Active in vivo. GSK-690693 induces hyperglycemia. Cell permeable.

References/Citations
1) Rhodes et al. (2008), Characterization of an Akt kinase inhibitor with potent pharmacodynamics and antitumor activity; Cancer Res., 68 2366
2) Crouthamel et al. (2009), Mechanism and management of AKT inhibitor-induced hyperglycemia; Clin. Cancer Res., 15 217

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Focus Biomolecules cell signaling reagent supplier, chemical structure GSK-690693 HCl | AKT inhibitor | CAS 937174-76-0

Catalog#  10-1310

$98.00
Quantity
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CAS:
937174-76-0
Catalog Number:
10-1310
Activity:
AKT inhibitor
Chemical Name:
(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridine-4-yl)-2-methylbut-3-yn-2-ol HCl
Molecular Weight:
461.96
Molecular Formula:
C21H27N7O3 HCl
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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