my account
Login
  Loading... Please wait...

Product Details

GSK417651A | TRPC3/6 blocker

GSK417651A is a TRPC inhibitor. In whole-cell patch-clamp experiments in HEK293 cells transfected with recombinant human TRPC3 or TRPC6, GSK417651A inhibited both TRPC3 and TRPC6 current with IC50 of ~0.04 μM.1 Combined pharmacological blockade of TRPC3 and TRPC6 inhibits cardiac hypertrophy.2 Cell permeable

References/Citations
1) Xu et al. (2013), Characterization of small molecule TRPC3 and TRPC6 agonists and antagonists; Biophys. J., 104 Supp 1 454a
2)
Seo et al. (2014) Combined TRPC3 and TRPC6 blckade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy; Proc. Natl. Acad. Sci. USA, 111 1551

swipe
GSK-417651A | Structure | Supplier

Catalog#  10-1434

$100.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
Not Available
Catalog Number:
10-1434
Activity:
TRPC3/6 blocker
Chemical Name:
(3,4-dihydroisoquinolin-2(1H)-yl)(2-((4-methoxyphenyl)amino)thiazol-4-yl)methanone
Molecular Weight:
365.46
Molecular Formula:
C20H19N3O2S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Physical Properties:
Yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the GSK417651A | TRPC3/6 blocker to your wish list.