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GSK872 | Necroptosis inhibitor / RIP3 inhibitor

GSK 872 is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 µM).2

References/Citations

1) Kaiser et al. (2013) Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL; J. Biol. Chem. 288 31279
2) Mandal et al. (2014) RIP3 induces apoptosis independent of pro-necrotic kinase activity; Mol. Cell 56 481

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Catalog#  10-4861-0005

$70.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1346546-69-7
Catalog Number:
10-4861
Activity:
Necroptosis inhibitor / RIP3 inhibitor
Chemical Name:
N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
Alternate Names:
GSK2399872A
Molecular Weight:
383.49
Molecular Formula:
C19H17N3O2S2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-White or pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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