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Product Details

GW1100 | GPR40 antagonist

GW1100 (305974-70-9) is a selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 (Cat.# 10-1108) or linoleic acid (pIC50 = 5.99 for either agonist).1 The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120.

References/Citations
1) Brisco et al. (2006), Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist molecules; Br. J. Pharmacol., 148 619
2) Nagatake et al. (2018), The 17,18-Epoxytetraenoic acid-G protein-coupled receptor 40 axis amelioraters contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques; J. Allergy Clin. Immunol., 142 470 [Focus Biomolecules Citation]

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Catalog#  10-4516

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
305974-70-9
Catalog Number:
10-4516
Activity:
GPR40 antagonist
Chemical Name:
1-(4-Ethoxycarbonylphenyl-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone
Molecular Weight:
520.59
Molecular Formula:
C27H25FN4O4S
Solubility:
Soluble in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
96% by LCMS
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSOor DMF may be stored at -20° for up to 3 months. Dilutions into aquoeus media are not stable and should be used within one working day.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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