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Product Details

H-151 | STING Antagonist

H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.

References/Citations

1) Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269

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Catalog#  10-4132-0010

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
941987-60-6
Catalog Number:
10-4132
Activity:
STING Antagonist
Chemical Name:
N-(4-Ethylphenyl)-N’-1H-indol-3-yl urea
Molecular Weight:
279.34
Molecular Formula:
C17H17N3O
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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