my account
Login
  Loading... Please wait...

Product Details

H-89 2HCl | PKA inhibitor

H-89 (127243-85-0) is a commonly used inhibitor of protein kinase A (PKA  IC50 = 140 nM).  Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).1,2

References/Citations

1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261
2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297

swipe
Image 1

Catalog#  10-2144-0005

$80.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
127243-85-0
Catalog Number:
10-2144
Activity:
PKA inhibitor
Chemical Name:
N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
Molecular Weight:
519.28
Molecular Formula:
C20H20BrN3O2S • 2HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Water (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the H-89 2HCl | PKA inhibitor to your wish list.